RNA Details
Disease Name
pulmonary fibrosis
Tissue
lung
RNA Symbol
TGFB1
RNA ID
RNA Type
mRNA
Alteration Pattern
histone hyperacetylation
Species
homo sapiens
Detection Methods
qRT-PCR; ELISA etc.
Target
NA
Pathway
NF-kappaB signaling pathway; AP-1 signaling pathway
PubMed ID
Title
NF-kappaB and activator protein 1 response elements and the role of histone modifications in IL-1beta-induced TGF-Beta1 gene transcription
Year
2006
Function
"IL-1beta-stimulated transcription of TGF-Beta1 is temporally regulated by NF-kappaB and AP-1 and involves histone H3, H4 hyperacetylation at distinct promoter sites."